Benchmark Dose Models Included in BMDS¶

Most of the models in the following tables were developed by U.S. EPA and are available in BMDS, unless otherwise noted.

Some models are flagged as available only in BMDS 2.7. The BMDS 2.7 and BMDS 3.3 software packages are available for download but are no longer supported or updated by EPA.

Table 1. List of Maximum-Likelihood Estimation Continuous Models¶
Model	BMDS 2.7	BMDS 3.3	BMDS Online/Desktop/pybmds
Exponential	Yes	Yes	Yes
Hill	Yes	Yes	Yes
Linear	Yes	Yes	Yes
Polynomial	Yes	Yes	Yes
Power	Yes	Yes	Yes

Table 2. List of Maximum-Likelihood Estimation Dichotomous Models¶
Model	BMDS 2.7	BMDS 3.3	BMDS Online/Desktop/pybmds
Gamma	Yes	Yes	Yes
Logistic	Yes	Yes	Yes
Log-Logistic	Yes	Yes	Yes
Log-Probit	Yes	Yes	Yes
Multistage	Yes	Yes	Yes
Probit	Yes	Yes	Yes
Weibull	Yes	Yes	Yes
Quantal Linear	Yes	Yes	Yes
Dichotomous Hill	Yes	Yes	Yes

Table 3. List of Maximum-Likelihood Estimation Nested Dichotomous Models¶
Model	BMDS 2.7	BMDS 3.3	BMDS Online/Desktop/pybmds
Nested Logistic	Yes	Yes	Yes
National Center for Toxicological Research (NCTR)	Yes	No	Yes
Rai and Van Ryzin (No longer supported)	Yes	No	No

Table 4. List of Specialized Models¶
Model	BMDS 2.7	BMDS 3.3	BMDS Online/Desktop/pybmds
Bayesian Model Averaging (Dichotomous)	No	Yes	Yes
Multistage Cancer/Multitumor	Yes	Yes	Yes

Models Not Included in BMDS Online¶

BMDS Online contains all the models and features that were available in BMDS 2.7 except for:

The Dichotomous background-dose models, which were rarely used.
The Rai and Van Ryzin nested dichotomous model, which was not included in BMDS due to the planned inclusion, and increased reliability, of the Nested Logistic and NCTR models.
The ToxicoDiffusion model—also known as Repeated Response Measures— was not included because it required R to be installed on the target computer.
The Ten Berge Concentration x Time model, which was superseded by EPA’s categorical regression software CatReg. CatReg has the same functionality but with added features and options.

All these models — excluding CatReg — can be accessed in BMDS 2.7, which is available from the BMDS website. CatReg is a Windows-based dose-time-response software package that can be downloaded from the BMDS website.